A custom-designed multi-organ-on-a-chip (MOC) platform that connects human lung and liver tissue models through a microfluidic circuit, enabling crosstalk between organs for more realistic toxicity assessment.
The platform includes a custom PEEK chip with separate lung and liver compartments, a precision perfusion system with programmable flow rates, and a reservoir plate for media exchange. The complete fluidic circuit was designed to maintain cell viability during extended experimental protocols while enabling aerosol exposure on the lung compartment.
This project demonstrates our capability to design and build complex microfluidic systems integrating mechanical engineering, precision fluid handling, and biological compatibility requirements.